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in chronological order:

* To whom correspondence should be addressed


Reisky, L., Büchsenschütz, H. C., Engel, J., Song, T., Schweder, T., Hehemann, J.-H.*, & Bornscheuer, U. T.* (2018). Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases. Nature Chemical Biology. https://doi.org/10.1038/s41589-018-0005-8

The CAZypedia Consortium. (2017). Ten years of CAZypedia: A living encyclopedia of carbohydrate-active enzymes. Glycobiology. https://doi.org/10.1093/glycob/cwx089

Robb, C. S., Mystkowska, A. A., & Hehemann, J.-H.* (2017). Crystal structure of a marine glycoside hydrolase family 99 related protein lacking catalytic machinery. Protein Science. https://doi.org/10.1002/pro.3291

Badur, A. H., Plutz, M. J., Yalamanchili, G., Jagtap, S. S., Schweder, T., Unfried, F., Markert S., Polz M. F., Hehemann J.-H.*, Rao, C. V.* (2017). Exploiting Fine-scale Genetic and Physiological Variation of Closely Related Microbes to Reveal Unknown Enzyme Functions. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M117.787192

Li, D., Yewalkar, S., Bi, X., Duff, S., Posarac, D., Wang, H., Woodfin, L. A., Hehemann, J.-H., Potter, S. C., Nano, F. E. (2017). Heterologous expression of LamA gene encoded endo-β-1,3-glucanase and CO2 fixation by bioengineered Synechococcus sp. PCC 7002. Frontiers of Environmental Science & Engineering, 11(2), 9. https://doi.org/10.1007/s11783-017-0910-1

Hehemann, J.-H.*, Truong, L. Van, Unfried, F., Welsch, N., Kabisch, J., Heiden, S. E., … Schweder, T.* (2017). Aquatic adaptation of a laterally acquired pectin degradation pathway in marine Gammaproteobacteria. Environmental Microbiology. https://doi.org/10.1111/1462-2920.13726

Becker, S., Scheffel, A., Polz, M. F., & Hehemann, J.-H.* (2017). Accurate quantification of laminarin in marine organic matter with enzymes from marine microbes. Applied and Environmental Microbiology. https://doi.org/10.1128/AEM.03389-16

Hehemann, J.-H., Arevalo, P., Datta, M. S., Yu, X., Corzett, C. H., Henschel, A., … Polz, M. F. (2016). Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes. Nature Communications, 7, 12860. https://doi.org/10.1038/ncomms12860

Hobbs, J. K., Lee, S. M., Robb, M., Hof, F., Barr, C., Abe, K. T., Hehemann J.-H., McLean R., Abbott D. W., Boraston, A. B. (2016). KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate. Proceedings of the National Academy of Sciences of the United States of America, 113(22), 6188–6193. https://doi.org/10.1073/pnas.1524214113

Labourel, A., Jam, M., Legentil, L., Sylla, B., Hehemann, J. H., Ferrieres, V., … Michel, G. (2015). Structural and biochemical characterization of the laminarinase ZgLamCGH16 from Zobellia galactanivorans suggests preferred recognition of branched laminarin. Acta Crystallographica. Section D, Biological Crystallography, 71(Pt 2), 173–184. https://doi.org/10.1107/S139900471402450X

Hehemann, J.-H.*, Boraston, A. B., & Czjzek, M.* (2014). A sweet new wave: structures and mechanisms of enzymes that digest polysaccharides from marine algae. Current Opinion in Structural Biology, 28, 77–86. https://doi.org/10.1016/j.sbi.2014.07.009

Hehemann, J.-H.*, Law, A., Redecke, L., & Boraston, A. B.* (2014). The structure of RdDddP from Roseobacter denitrificans reveals that DMSP lyases in the DddP-family are metalloenzymes. PloS One, 9(7), e103128. https://doi.org/10.1371/journal.pone.0103128

Jagtap, S. S., Hehemann, J.-H., Polz, M. F., Lee, J.-K., & Zhao, H. (2014). Comparative biochemical characterization of three exolytic oligoalginate lyases from Vibrio splendidus reveals complementary substrate scope, temperature, and pH adaptations. Applied and Environmental Microbiology, 80(14), 4207–4214. https://doi.org/10.1128/AEM.01285-14

Labourel, A., Jam, M., Jeudy, A., Hehemann, J.-H., Czjzek, M., & Michel, G. (2014). The β-glucanase ZgLamA from Zobellia galactanivorans evolved a bent active site adapted for efficient degradation of algal laminarin. The Journal of Biological Chemistry, 289(4), 2027–42. https://doi.org/10.1074/jbc.M113.538843

Pagarete, A., Kusonmano, K., Petersen, K., Kimmance, S. A., Martinez Martinez, J., Wilson, W. H., Hehemann J.-H., Allen M. J., Sandaa, R.-A. (2014). Dip in the gene pool: metagenomic survey of natural coccolithovirus communities. Virology, 466–467, 129–137. https://doi.org/10.1016/j.virol.2014.05.020

Yawata, Y., Cordero, O. X., Menolascina, F., Hehemann, J.-H., Polz, M. F., & Stocker, R. (2014). Competition-dispersal tradeoff ecologically differentiates recently speciated marine bacterioplankton populations. Proceedings of the National Academy of Sciences of the United States of America, 111(15), 5622–5627. https://doi.org/10.1073/pnas.1318943111

Pluvinage, B., Hehemann, J.-H., & Boraston, A. B. (2013). Substrate recognition and hydrolysis by a family 50 exo-beta-agarase, Aga50D, from the marine bacterium Saccharophagus degradans. The Journal of Biological Chemistry, 288(39), 28078–28088. https://doi.org/10.1074/jbc.M113.491068

Hehemann, J.-H., Correc, G., Thomas, F., Bernard, T., Barbeyron, T., Jam, M., … Czjzek, M. (2012). Biochemical and structural characterization of the complex agarolytic enzyme system from the marine bacterium Zobellia galactanivorans. The Journal of Biological Chemistry, 287(36), 30571–84. https://doi.org/10.1074/jbc.M112.377184

Hehemann, J.-H., Kelly, A. G., Pudlo, N. A., Martens, E. C., & Boraston, A. B. (2012). Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes. Proceedings of the National Academy of Sciences of the United States of America, 109(48), 19786–19791. https://doi.org/10.1073/pnas.1211002109

Hehemann, J.-H., Smyth, L., Yadav, A., Vocadlo, D. J., & Boraston, A. B. (2012). Analysis of keystone enzyme in Agar hydrolysis provides insight into the degradation (of a polysaccharide from) red seaweeds. The Journal of Biological Chemistry, 287(17), 13985–95. https://doi.org/10.1074/jbc.M112.345645

Correc, G., Hehemann, J.-H., Czjzek, M., & Helbert, W. (2011). Structural analysis of the degradation products of porphyran digested by Zobellia galactanivorans β-porphyranase A. Carbohydrate Polymers, 83(1), 277–283. https://doi.org/10.1016/j.carbpol.2010.07.060

Gregg, K. J., Zandberg, W. F., Hehemann, J.-H., Whitworth, G. E., Deng, L., Vocadlo, D. J., & Boraston, A. B. (2011). Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans. The Journal of Biological Chemistry, 286(17), 15586–15596. https://doi.org/10.1074/jbc.M111.223172

Hehemann, J.-H., Marsters, C., & Boraston, A. B. (2011). Ab initio phasing of a nucleoside hydrolase-related hypothetical protein from Saccharophagus degradans that is associated with carbohydrate metabolism. Proteins, 79(10), 2992–2998. https://doi.org/10.1002/prot.23126

Lammerts van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J.-H., Higgins, M. A., Deng, L., … Boraston, A. B. (2011). The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (London, England : 1993), 19(5), 640–651. https://doi.org/10.1016/j.str.2011.03.001

Thomas, F., Hehemann, J. H., Rebuffet, E., Czjzek, M., & Michel, G. (2011). Environmental and gut Bacteroidetes: The food connection. Frontiers in Microbiology, 2(MAY), 1–16. https://doi.org/10.3389/fmicb.2011.00093

Hehemann, J. H., Michel, G., Barbeyron, T., & Czjzek, M. (2010). Expression, purification and preliminary X-ray diffraction analysis of the catalytic module of a beta-agarase from the flavobacterium Zobellia galactanivorans. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 66(Pt 4), 413–417. https://doi.org/10.1107/S174430911000429X

Hehemann, J.-H., Correc, G., Barbeyron, T., Helbert, W., Czjzek, M., & Michel, G. (2010). Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature, 464(7290), 908–12. https://doi.org/10.1038/nature08937

Ficko-Blean, E., Gregg, K. J., Adams, J. J., Hehemann, J.-H., Czjzek, M., Smith, S. P., & Boraston, A. B. (2009). Portrait of an enzyme, a complete structural analysis of a multimodular {beta}-N-acetylglucosaminidase from Clostridium perfringens. The Journal of Biological Chemistry, 284(15), 9876–9884. https://doi.org/10.1074/jbc.M808954200

Hehemann, J.-H., Redecke, L., Murugaiyan, J., von Bergen, M., Betzel, C., & Saborowski, R. (2008). Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus. Biochemical and Biophysical Research Communications, 370(4), 566–571. https://doi.org/10.1016/j.bbrc.2008.03.128

Hehemann, J.-H., Redecke, L., Perbandt, M., Saborowski, R., & Betzel, C. (2007). Crystallization and preliminary X-ray diffraction studies of trypsin-like proteases from the gastric fluid of the marine crab Cancer pagurus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 63(Pt 3), 242–245. https://doi.org/10.1107/S1744309107008524