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Dr. Silvia Vidal Melgosa

Associated Research Staff

Group: 

Glycobiochemistry

Phone: 

+49 421 218-65965

Fax:

+49 421 218-65715

Email:

Room: 

MARUM Pavillon, 1060

Silvia Vidal Melgosa

Research Interests

  • Marine carbon cycle
  • Organic matter export via marine sinking particles
  • Marine glycobiology
  • Polysaccharide composition of microalgae and their exudates
  • Cell wall biology
  • Carbohydrate-active enzymes
  • Carbohydrate-specific molecular probes

CV

From October 2015

Postdoctoral Fellow at Prof. Dr. Jan-Hendrik Hehemann lab. Marine Gycobiology group. The Max Planck Institute for Marine Microbiology and MARUM Cen­ter for Mar­ine En­vir­on­mental Sci­ences at the Uni­versity of Bremen, Germany.

2011-2015                                                                                             

Doctor’s degree, Doctor in Biotechnology. Supervisor: Prof. William G. T. Willats. Department of Plant and Environmental Sciences, University of Copenhagen, Denmark. PhD within the Marie Curie Innovative Training Network and the 7th Framework Programme. Dissertation: “Development and application of a new microarray-based method for high-throughput screening of carbohydrate active enzymes”.

2005-2009

Master’s degree in Food Science and Technology. Barcelona University, Spain. 

Exchange student (August 2007-July 2008). University of Copenhagen, Denmark. Internship at the Department of Food Science (February-July). Investigating alcohol-based quorum sensing in dairy-relevant microorganisms.

2000-2005

Diploma in Biology. Barcelona University, Spain. Health biology specialisation (2003-2005). Bachelor’s degree in Biology (2000-2003).

 

Publications

  • Vidal-Melgosa, S., Sichert, A., Francis, T.B., Bartosik, D., Niggemann, J., Wichels, A., Willats, W.G.T., Fuchs, B.M., Teeling, H., Becher, D., Schweder, T., Amann, R., Hehemann, J. H. (2021). Diatom fucan polysaccharide precipitates carbon during algal blooms. Nature Communications, 12(1), 1150.
  • Guo, S., Vance, T.D.R., Zahiri, H., Eves, R., Stevens, C., Hehemann, J.-H., Vidal-Melgosa, S., Davies, P.L. (2021). Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi-species biofilm formation. mBio (Accepted).
  • Parsons, H.T., Stevens, T.J., McFarlane, H.E., Vidal-Melgosa, S., Griss, J., Lawrence, N., Butler, R., Sousa, M.M.L., Salemi, M., Willats, W.G.T., Petzold, C.J., Heazlewood, J.L., Lilley, K.S. (2019). Separating Golgi proteins from cis to trans reveals underlying properties of cisternal localization. The Plant Cell, 31(9), 2010-2034.
  • Koch H., Dürwald A., Schweder T., Noriega-Ortega B., Vidal-Melgosa S., Hehemann J.-H., Dittmar T., Freese H.M., Becher D., Simon M., Wietz M. (2019). Biphasic cellular adaptations and ecological implications of Alteromonas macleodii degrading a mixture of algal polysaccharides. The ISME Journal, 13(1), 92-103.
  • Mystkowska, A.A., Robb, C., Vidal‐Melgosa, S., Vanni, C., Fernandez‐Guerra, A., Höhne, M., Hehemann, J.-H. (2018). Molecular recognition of the beta‐glucans laminarin and pustulan by a SusD‐like glycan‐binding protein of a marine Bacteroidetes. The FEBS Journal, 285(23), 4465-4481.
  • Baum, A., Dominiak, M., Vidal-Melgosa, S., Willats, W.G.T., Søndergaard, K.M., Hansen, P.W., Meyer, A.S., Mikkelsen, J.D. (2017). Prediction of pectin yield and quality by FTIR and carbohydrate microarray analysis. Food and Bioprocess Technology, 10(1), 143-154.
  • Kračun, S.K., Fangel, J.U., Rydahl, M.G., Pedersen, H.L., Vidal-Melgosa, S., Willats, W.G.T. (2017). Carbohydrate microarray technology applied to high-throughput mapping of plant cell wall glycans using comprehensive microarray polymer profiling (CoMPP). High-Throughput Glycomics and Glycoproteomics. Methods in Molecular Biology, 1503, 147-165.
  • Venditto I., Luis A.S., Rydahl M., Schückel J., Fernandes V.O., Vidal-Melgosa S., Bule P., Goyal A., Pires V.M., Dourado C.G., Ferreira L.M., Coutinho P.M., Henrissat B., Knox J.P., Baslé A., Najmudin S., Gilbert H.J., Willats W.G., Fontes C.M. (2016). Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. Proceedings of the National Academy of Sciences, 113(26), 7136-7141.
  • Vidal-Melgosa, S., Pedersen, H.L., Schückel, J., Arnal, G., Dumon, C., Amby, D., Monrad, R.N., Westereng, B., Willats, W.G.T. (2015). A new versatile microarray-based method for high-throughput screening of carbohydrate-active enzymes. The Journal of Biological Chemistry, 290(14), 9020-9036.
  • Johnsen, H.R., Striberny, B., Olsen, S., Vidal-Melgosa, S., Fangel, J.U., Willats, W.G.T., Rose, J.C., Krause, K. (2015). Cell wall composition profiling of parasitic giant dodder (Cuscuta reflexa) and its hosts:a priori differences and induced changes. New Phytologist, 207(3), 805-816.
  • Feng, T., Nyffenegger, C., Højrup, P., Vidal-Melgosa, S., Yan, K.P., Fangel, J.U., Meyer, A.S., Kirpekar, F., Willats, W.G., Mikkelsen, J.D. (2014). Characterization of an extensin-modifying metalloprotease: N-terminal processing and substrate cleavage pattern of Pectobacterium carotovorum Prt1. Applied Microbiology and Biotechnology, 98(24), 10077-10089.
  • Dominiak, M., Søndergaard, K.M., Wichmann, J., Vidal-Melgosa, S., Willats, W.G.T., Meyer, A.S., Mikkelsen, J.D. (2014). Application of enzymes for efficient extraction, modification, and development of functional properties of lime pectin. Food Hydrocolloids, 40, 273-282.
  • Agger, J.W., Isaksen, T., Várnai, A., Vidal-Melgosa, S., Willats, W.G.T., Ludwig, R., Horn, S.J., Eijsink, V.G.H., Westereng, B. (2014). Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation. Proceedings of the National Academy of Sciences, 111, 6287-6292.
  • Fangel, J.U., Pedersen, H.L., Vidal-Melgosa, S., Ahl, L.I., Salmean, A.A., Egelund, J., Rydahl, M.G., Clausen, M.H., Willats, W.G.T. (2012). Carbohydrate microarrays in plant science. High-Throughput Phenotyping in Plants. Methods in Molecular Biology, 918, 351-362.

 

Patents

  • Vidal-Melgosa, S., Hehemann, J.-H. (2019). Fucoidans from diatoms. International patent. Publication number WO2019211442, filed 4 May 2018. Publication date: 07/11/2019.
  • Willats, W.G.T., Vidal-Melgosa, S. (2013). High throughput screening of glycosyl hydrolase enzymes. International patent. World Intellectual Property Organization. Publication number WO2013135245. Publication date: 19/09/2013.